Triangulating causality between childhood obesity and neurobehavior: Behavioral genetic and longitudinal evidence.

Childhood obesity is a serious health concern that is not yet fully understood. Previous research has linked obesity with neurobehavioral factors such as behavior, cognition, and brain morphology. The causal directions of these relationships remain mostly untested. We filled this gap by using the Adolescent Brain Cognitive Development study cohort comprising 11,875 children aged 9-10. First, correlations between the age- and sex-specific 95th BMI percentile (%BMIp95) and neurobehavioral measures were cross-sectionally analyzed. Effects were then aggregated by neurobehavioral domain for causal analyses. Behavioral genetic Direction of Causation modeling was used to test the direction of each relationship. Findings were validated by longitudinal cross-lagged panel modeling. %BMIp95 correlated with impulsivity, motivation, psychopathology, eating behavior, and cognitive tests (executive functioning, language, memory, perception, working memory). Greater %BMIp95 was also associated with reduced cortical thickness in frontal and temporal brain areas but with increased thickness in parietal and occipital areas. Similar although weaker patterns emerged for cortical surface area and volume. Behavioral genetic modeling suggested causal effects of %BMIp95 on eating behavior (ß = 0.26), cognition (ß = 0.05), cortical thickness (ß = 0.15), and cortical surface area (ß = 0.07). Personality/psychopathology (ß = 0.09) and eating behavior (ß = 0.16) appeared to influence %BMIp95. Longitudinal evidence broadly supported these findings. Results regarding cortical volume were inconsistent. Results supported causal effects of obesity on brain functioning and morphology. The present study highlights the importance of physical health for brain development and may inform interventions aimed at preventing or reducing pediatric obesity. RESEARCH HIGHLIGHTS: A continuous measure related to obesity, %BMIp95, has correlations with various measures of brain functioning and structure Behavioral genetic and longitudinal modeling suggest causal links from personality, psychopathology, and eating behavior to %BMIp95 Results also indicate directional links from %BMIp95 to eating behavior, cognition, cortical thickness, and cortical surface area Obesity may play a role for healthy brain development during childhood.

Testing the factor structure and measurement invariance of the Temporal Experience of Pleasure Scale in adolescents across time, gender, and race/ethnicity.

The Temporal Experience of Pleasure Scale (TEPS) is a self-report measure designed to assess anticipatory and consummatory pleasure, two facets of anhedonic predispositions. Despite its widespread use, the factor structure of the TEPS has yet to be tested in adolescents, who are at increased risk for psychopathology and undergoing rapid changes in reward-related processes. In response, the present study aimed to test the factor structure and measurement invariance of the TEPS across time, gender, and race/ethnicity in a diverse adolescent sample. Adolescents (N = 441; Mage = 14.98; 223 female) who identified as either Black (37%), Hispanic (37%), or White (26%), completed the TEPS at Baseline, 6-month, and 12-month follow-ups. Factor analyses were conducted to examine the factor structure of the TEPS, while configural, metric, scalar, and strict invariance were tested across time and demographics. Findings supported the two-factor structure of the TEPS, above and beyond other conceptualizations (e.g., 4-factor, bifactor), full longitudinal invariance, and partial invariance across gender and race/ethnicity. Examination of mean differences suggested no temporal, gender nor race/ethnic differences for anticipatory pleasure. For consummatory pleasure, no differences were found for gender, but results suggested higher levels over time and lower levels in Black adolescents. Our findings provide preliminary support for reliable cross-group interpretations of anticipatory and consummatory anhedonic predispositions as measured through the TEPS. Together, results provide support for the clinical utility of the TEPS for anhedonic-related psychopathology risk assessment in adolescence. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Two genetic analyses to elucidate causality between body mass index and personality.

BACKGROUND/OBJECTIVES: Many personality traits correlate with BMI, but the existence and direction of causal links between them are unclear. If personality influences BMI, knowing this causal direction could inform weight management strategies. Knowing that BMI instead influences personality would contribute to a better understanding of the mechanisms of personality development and the possible psychological effects of weight change. We tested the existence and direction of causal links between BMI and personality. SUBJECTS/METHODS: We employed two genetically informed methods. In Mendelian randomization, allele scores were calculated to summarize genetic propensity for the personality traits neuroticism, worry, and depressive affect and used to predict BMI in an independent sample (N = 3 541). Similarly, an allele score for BMI was used to predict eating-specific and domain-general phenotypic personality scores (PPSs; aggregate scores of personality traits weighted by BMI). In a direction of causation (DoC) analysis, twin data from five countries (N = 5424) were used to assess the fit of four alternative models: PPSs influencing BMI, BMI influencing PPSs, reciprocal causation, and no causation. RESULTS: In Mendelian randomization, the allele score for BMI predicted domain-general (ß = 0.05; 95% CI: 0.02, 0.08; P = 0.003) and eating-specific PPS (ß = 0.06; 95% CI: 0.03, 0.09; P < 0.001). The allele score for worry also predicted BMI (ß = -0.05; 95% CI: -0.08, -0.02; P < 0.001), while those for neuroticism and depressive affect did not (P ≥ 0.459). In DoC, BMI similarly predicted domain-general (ß = 0.21; 95% CI:, 0.18, 0.24; P < 0.001) and eating-specific personality traits (ß = 0.19; 95% CI:, 0.16, 0.22; P < 0.001), suggesting causality from BMI to personality traits. In exploratory analyses, links between BMI and domain-general personality traits appeared reciprocal for higher-weight individuals (BMI > ~25). CONCLUSIONS: Although both genetic analyses suggested an influence of BMI on personality traits, it is not yet known if weight management interventions could influence personality. Personality traits may influence BMI in turn, but effects in this direction appeared weaker.

Association of Wealth With Longevity in US Adults at Midlife.

Importance: Wealthy adults tend to live longer than those with less wealth. However, a challenge in this area of research has been the reduction of potential confounding by factors associated with the early environment and heritable traits, which could simultaneously affect socioeconomic circumstances in adulthood and health across the life course. Objective: To identify the association between net worth at midlife and subsequent all-cause mortality in individuals as well as within siblings and twin pairs. Design Setting and Participants: This cohort study conducted a series of analyses using data from the Midlife in the United States (MIDUS) study, an ongoing national study of health and aging. The sample included adults (unrelated individuals, full siblings, and dizygotic and monozygotic twins) aged 20 to 75 years, who participated in wave 1 of the MIDUS study, which occurred from 1994 to 1996. The analyses were conducted between November 16, 2019, and May 18, 2021. Exposures: Self-reported net worth (total financial assets minus liabilities) at midlife (the middle years of life). Main Outcomes and Measures: All-cause mortality was tracked over nearly 24 years of follow-up, with a censor date of October 31, 2018. Survival models tested the association between net worth and all-cause mortality. Discordant sibling and twin analyses compared longevity within siblings and twin pairs who, given their shared early experiences and genetic backgrounds, were matched on these factors. Results: The full sample comprised 5414 participants, who had a mean (SD) age of 46.7 (12.7) years and included 2766 women (51.1%). Higher net worth was associated with lower mortality risk (hazard ratio [HR], 0.95; 95% CI, 0.94-0.97; P < .001). Among siblings and twin pairs specifically (n = 2490), a similar within-family association was observed between higher net worth and lower mortality (HR, 0.94; 95% CI, 0.91-0.97; P = .001), suggesting that the sibling or twin with more wealth tended to live longer than their co-sibling or co-twin with less wealth. When separate estimates were performed for the subsamples of siblings (HR, 0.94; 95% CI, 0.90-0.97; P = .002), dizygotic twins (HR, 0.94; 95% CI, 0.86-1.02; P = .19), and monozygotic twins (HR, 0.95; 95% CI, 0.87-1.04; P = .34), the within-family estimates of the net worth-mortality association were similar, although the precision of estimates was reduced among twins. Conclusions and Relevance: This cohort study found that wealth accumulation at midlife was associated with longevity in US adults. Discordant sibling analyses suggested that this association is unlikely to be simply an artifact of early experiences or heritable characteristics shared by families.

Weak and uneven associations of home, neighborhood, and school environments with stress hormone output across multiple timescales.

The progression of lifelong trajectories of socioeconomic inequalities in health and mortality begins in childhood. Dysregulation in cortisol, a stress hormone that is the primary output of the hypothalamus-pituitary-adrenal (HPA) axis, has been hypothesized to be a mechanism for how early environmental adversity compromises health. However, despite the popularity of cortisol as a biomarker for stress and adversity, little is known about whether cortisol output differs in children being raised in socioeconomically disadvantaged environments. Here, we show that there are few differences between advantaged and disadvantaged children in their cortisol output. In 8-14-year-old children from the population-based Texas Twin Project, we measured cortisol output at three different timescales: (a) diurnal fluctuation in salivary cortisol (n = 400), (b) salivary cortisol reactivity and recovery after exposure to the Trier Social Stress Test (n = 444), and (c) cortisol concentration in hair (n = 1210). These measures converged on two moderately correlated, yet distinguishable, dimensions of HPA function. We tested differences in cortisol output across nine aspects of social disadvantage at the home (e.g., family socioeconomic status), school (e.g., average levels of academic achievement), and neighborhood (e.g., concentrated poverty). Children living in neighborhoods with higher concentrated poverty had higher diurnal cortisol output, as measured in saliva; otherwise, child cortisol output was unrelated to any other aspect of social disadvantage. Overall, we find limited support for alteration in HPA axis functioning as a general mechanism for the health consequences of socioeconomic inequality in childhood.

Personality Changes Predict Early Career Outcomes: Discovery and Replication in 12-Year Longitudinal Studies.

In this research, we examined whether personality changes from adolescence to young adulthood predicted five early career outcomes: degree attainment, income, occupational prestige, career satisfaction, and job satisfaction. The study used two representative samples of Icelandic youth (Sample 1: n = 485, Sample 2: n = 1,290) and measured personality traits over 12 years (ages ~17 to 29 years). Results revealed that certain patterns of personality growth predicted career outcomes over and above adolescent trait levels and crystallized ability. Across both samples, the strongest effects were found for growth in emotional stability (income and career satisfaction), conscientiousness (career satisfaction), and extraversion (career satisfaction and job satisfaction). Initial trait levels also predicted career success, highlighting the long-term predictive power of personality. Overall, our findings show that personality has important effects on early career outcomes-both through stable trait levels and how people change over time. We discuss implications for public policy, for theoretical principles of personality development, and for young people making career decisions.

Adolescent Big Five personality and pubertal development: Pubertal hormone concentrations and self-reported pubertal status.

In early adolescence, levels of conscientiousness and agreeableness have been found to temporarily decrease, with levels of neuroticism increasing, indicating a dip in personality maturation. It is unknown whether these changes are related to the process of puberty, a major developmental milestone with numerous changes for children. Here, we first replicated the dip in personality maturity in early adolescence (N = 2640, age range 8-18, 51% girls, 65% non-Hispanic white, 21% Hispanic/Latino, 10% African American, 9% other, roughly 33% of families received means-tested public assistance) and tested associations between the Big Five personality dimensions and pubertal development and timing across late childhood and adolescence (n = 1793). Pubertal development was measured using both hormonal assays (DHEA, testosterone, and progesterone) and self-reports of secondary sex characteristics. Of hormonal measures, only higher DHEA concentrations were associated with lower conscientiousness and openness. Nonparametric moderation analyses using LOSEM indicated Complex Age × Sex interactions involving all three hormones. Self-reported pubertal development was associated with lower extraversion, conscientiousness, agreeableness, and openness. More advanced pubertal timing was also related to lower levels of extraversion, conscientiousness, and agreeableness. All associations were small. As some evidence was found for small associations between pubertal development and lower levels of conscientiousness and agreeableness, a dip in personality maturation in these personality traits may be partly due to pubertal development in early adolescence. Overall, results did not indicate that pubertal development was the primary explanation of the maturity dip in adolescent personality. Many small influences likely accumulate to explain the dip in personality maturity in early adolescence. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Childhood growth in math and reading differentially predicts adolescent non-ability-based confidence: An examination in the SECCYD.

Non-ability-based confidence is one of the most pervasive human psychological biases. It is a part of a family of confidence judgments, including overconfidence and metacognitive calibration accuracy, defined by a discrepancy between self-perception of ability and actual ability. Across many domains, most people exhibit some degree of miscalibration in their confidence. Some people may be overconfident and others are underconfident. Despite the prevalence of non-ability-based confidence, relatively little research has investigated how non-ability-based confidence develops and why some people are more or less confident than others despite sharing the same level of ability. We use a longitudinal dataset to explore the childhood predictors of adolescent non-ability-based confidence. Achievement growth in math and reading in childhood was modeled and used to predict adolescent non-ability-based confidence in math and reading. Results show that the initial level of achievement predicts lower non-ability-based confidence in math. On the other hand, a faster rate of achievement growth across childhood predicts greater non-ability-based confidence in reading. These results highlight how previous experiences inform people's self-perceptions over and above their true abilities. Discussion focuses on the factors that shape non-ability-based confidence over the lifespan and the limitations of the current findings.

Developmental structure of personality and interests: A four-wave, 8-year longitudinal study.

Personality traits and vocational interests capture different aspects of human individuality that intersect in certain ways. In this longitudinal study, we examined developmental relations between the Big 5 traits and RIASEC vocational interests over 4 timepoints from late adolescence to young adulthood (age 16-24) in a sample of Icelandic youth (N = 485) well-representative of the total student population. Results showed that interests and personality traits were similarly stable over time, but showed different patterns of mean-level change. There was evidence of personality maturation but a lack of cumulative changes in interest levels. For the most part, gender differences in developmental trends were minimal. In addition, latent growth curve analyses revealed broad and specific correlated changes between personality and interests. Changes in general factors of personality and interests were moderately related (r = .32), but stronger correlated changes were found among specific personality-interest pairs that share situational content. Overall, results reveal how interests and personality are related across different types of continuity and change. While there was little correspondence between group-level changes, substantial correlated change occurred at the individual level. This means that when a person's personality changes, their interests tend to change in predictable ways (and vice versa). Integrative theories that link different aspects of psychological functioning can benefit by incorporating these findings. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Genetic and Environmental Associations Between Child Personality and Parenting.

Parenting is often conceptualized in terms of its effects on offspring. However, children may also play an active role in influencing the parenting they receive. Simple correlations between parenting and child outcomes may be due to parent-to-child causation, child-to-parent causation, or some combination of the two. We use a multi-rater, genetically informative, large sample (n = 1411 twin sets) to gain traction on this issue as it relates to parental warmth and stress in the context of child Big Five personality. Considerable variance in parental warmth (27%) and stress (45%) was attributable to child genetic influences on parenting. Incorporating child Big Five personality into the model explained roughly half of this variance. This result is consistent with the hypothesis that parents mold their parenting in response to their child's personality. Residual heritability of parenting is likely due to child characteristics beyond the Big Five.

Genetic overlap between executive functions and BMI in childhood.

BACKGROUND: Executive functions (EFs) comprise a group of cognitive processes that selectively control and regulate attention. Inverse relations have been reported between EFs and BMI. However, the mechanisms underlying this association are not well understood. OBJECTIVES: We aimed to decompose the inverse relation between EFs and BMI into genetic and environmental components. METHODS: We employed a cross-sectional analysis of data from 869 twins aged 7-15 y from the Texas Twin Project, who completed a neuropsychological test battery measuring 4 EFs (switching, inhibitory control, working memory, and updating); academic achievement (reading and mathematics); and general cognitive abilities (general intelligence/intelligence quotient; crystallized and fluid intelligence; and processing speed). Participants also had their height and weight measured. RESULTS: After controlling for age, sex, and race/ethnicity, BMI was inversely associated with a general EF factor representing the capacity to control and regulate goal-oriented behaviors (r = -0.125; P = 0.01; Q = 0.04). This inverse BMI-EF association was due to a significant overlap in genetic factors contributing to each phenotype (genetic correlation, rA, = -0.15; P < 0.001). Shared genetic influences accounted for 80% of the phenotypic association. CONCLUSIONS: Children with higher general EF have lower BMIs, and this association is primarily attributable to shared genetic influences on both phenotypes. The results emphasize that higher weight associates not only with physical sequelae, but also with important cognitive attributes. This work adds to a growing body of research suggesting there are sets of genetic variants common across physical health and cognitive functioning.

National Gross Domestic Product, Science Interest, and Science Achievement: A Direct Replication and Extension of the Tucker-Drob, Cheung, and Briley (2014) Study.

We replicated the study by Tucker-Drob, Cheung, and Briley (2014), who found that the association between science interest and science knowledge depended on economic resources at the family, school, and national levels, using data from the 2006 Programme for International Student Assessment (PISA). In more economically prosperous families, schools, and nations, student interest was more strongly correlated with actual knowledge. Here, we investigated whether these results still held despite substantial changes to educational and economic systems over roughly a decade. Using similar data from PISA 2015 ( N = 537,170), we found largely consistent results. Students from more economically advantaged homes, schools, and nations exhibited a stronger link between interests and knowledge. However, these moderation effects were substantially reduced, and the main effect of science interest increased by nearly 25%, driven almost entirely by families of low socioeconomic status and nations with low gross domestic product. The interdependence of interests and resources is robust but perhaps weakening with educational progress.

Kids becoming less alike: A behavioral genetic analysis of developmental increases in personality variance from childhood to adolescence.

Recent work in personality development has indicated that the magnitude of individual differences in personality increases over child development. Do such patterns reflect the differentiation of individuals by genotype, an increasing influence of environmental factors, or some (interactive) combination of the two? Using a population-based sample of over 2,500 twins and multiples from the Texas Twin Project, we estimated age trends in the variances in self- and parent-reported measures of the Big Five personality traits between Ages 8 and 18 years. We then estimated age trends in the genetic and environmental components of variance in each measure. Individual differences in personality increased in magnitude from childhood through mid-adolescence. This pattern emerged using both children's self-reports and ratings provided by their parents, and was primarily attributable to increases in the magnitude of genetic influences. Most of the increasing genetic variance appeared nonadditive, pointing to the possibility that developmental processes tend to make genetically similar individuals disproportionately more alike in their personality traits over time. These findings could reflect increasing or accumulating effects of trait-by-trait interactions; person-by-environment transactions, whereby genetically similar people are disproportionally likely to experience similar environments; the activation of dominant genes across developmental transitions (e.g., puberty); or some combination of these three processes, among other factors. Theories of personality development will need to accommodate these descriptive findings, and longitudinal, genetically informed designs are needed to test some of the specific hypotheses springing from this study. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Interpreting Behavior Genetic Models: Seven Developmental Processes to Understand.

Behavior genetic findings figure in debates ranging from urgent public policy matters to perennial questions about the nature of human agency. Despite a common set of methodological tools, behavior genetic studies approach scientific questions with potentially divergent goals. Some studies may be interested in identifying a complete model of how individual differences come to be (e.g., identifying causal pathways among genotypes, environments, and phenotypes across development). Other studies place primary importance on developing models with predictive utility, in which case understanding of underlying causal processes is not necessarily required. Although certainly not mutually exclusive, these two goals often represent tradeoffs in terms of costs and benefits associated with various methodological approaches. In particular, given that most empirical behavior genetic research assumes that variance can be neatly decomposed into independent genetic and environmental components, violations of model assumptions have different consequences for interpretation, depending on the particular goals. Developmental behavior genetic theories postulate complex transactions between genetic variation and environmental experiences over time, meaning assumptions are routinely violated. Here, we consider two primary questions: (1) How might the simultaneous operation of several mechanisms of gene-environment (GE)-interplay affect behavioral genetic model estimates? (2) At what level of GE-interplay does the 'gloomy prospect' of unsystematic and non-replicable genetic associations with a phenotype become an unavoidable certainty?

You have to follow through: Attaining behavioral change goals predicts volitional personality change.

Prior research has found that people's desires to change their personality traits predict corresponding subsequent trait growth over time. However, few studies have examined the processes through which people can volitionally change their personality traits. Thus, it remains unclear whether merely desiring change predicts trait growth or whether actively pursuing change is necessary. The present study was a 15-week intensive longitudinal design that tested whether engaging in trait-typical behaviors predicted trait change. Participants provided self-report ratings of their personality traits and were able to freely accept and complete weekly "challenges"-prewritten behavioral goals that would pull their thoughts, feelings, and behaviors in line with their desired traits. Results indicated that merely accepting behavioral challenges did not predict trait changes. Rather, only actually completing challenges (i.e., performing trait-typical behaviors) predicted trait change over time. Thus, merely wanting to change does not appear to be sufficient to evoke trait growth; successfully changing one's personality traits may require actively and successfully implementing behaviors to change oneself. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Genetic and Environmental Influences on Achievement Goal Orientations Shift with Age.

Students engage in learning activities with different achievement goal orientations. Some students pursue learning for learning sake (i.e. mastery goal orientation), some are driven by gaining favorable judgement of their performance (i.e. performance approach goal orientation), and others focus on avoiding negative judgement (i.e. performance avoidance goal orientation). These goal orientations are linked with academic achievement, and troublingly, students report decreasing levels of goal orientations across the school years. However, little is known concerning the mechanisms that drive this decline. In a large (N = 891 twin pairs) cross-sectional genetically informative sample (age = 8 to 22 years), we found that older students reported lower goal orientations. Then, we identified shifts in the magnitude of genetic and environmental variance in each goal orientation. For example, variance in mastery goal orientation was primarily associated with environmental factors during the elementary school years. As students entered high school, genetic influences increased, replacing shared environmental influences. Finally, we situated these findings in the larger nomological network by testing associations with psychological constructs (e.g. personality and cognitive ability) and contextual variables (e.g. parents, schools, and peers). The development of academic motivation is complex with many interconnecting factors that appear to shift with age.

A meta-analysis of the association between substance use and emerging adult development using the IDEA scale.

BACKGROUND AND OBJECTIVES: Much debate exists surrounding Arnett's theory of emerging adulthood in terms of its breadth and application. Researchers have attempted to capture dimensions of emerging adulthood (eg, experimentation, negativity/instability, other-focus, self-focus, and feeling in-between) through self report assessment, using variations of the Inventory of the Dimensions of Emerging Adulthood or IDEA. Results from studies investigating this relationship have been mixed. We conducted a meta-analysis on the association between substance use and the IDEA. METHOD: Data were extracted to calculate correlational associations with substance use as well as typical moderators found in the literature. Twelve studies were meta-analyzed. RESULTS: We found small associations (range: ρ = -.03 to .15; d = .06 to 30) between the IDEA scores and substance use. We found higher severity (dependence diagnosis) of participants yielded larger associations across all dimensions (ρ = .16), and proportion of college students to be a subscale-specific moderator (experimentation, negativity/instability, other-focus, self-focus, and feeling in-between). Alcohol use outcomes also provided larger subscale-specific associations (experimentation, negativity/instability, other-focus, self-focus). CONCLUSIONS: The dimensions of emerging adulthood may be less effective in predicting substance use among non-college samples and those studies focusing on drug use. Further research should prioritize exploring variation in the transition to emerging adulthood among non-college samples and the longitudinal associations between IDEA and substance use. SCIENTIFIC SIGNIFICANCE: Important contributions include the modest association between IDEA and substance use as well as specific participant characteristics that amplify or mitigate the association between IDEA and substance use. (Am J Addict 2018;27:166-176).

Normative changes in interests from adolescence to adulthood: A meta-analysis of longitudinal studies.

Vocational interests predict a variety of important outcomes and are among the most widely applied individual difference constructs in psychology and education. Despite over 90 years of research, little is known about the longitudinal development of interests. In this meta-analysis, the authors investigate normative changes in interests through adolescence and young adulthood. Effect sizes were aggregated from 49 longitudinal studies reporting mean-level changes in vocational interests, containing 98 total samples and 20,639 participants. Random effects meta-analytic regression models were used to assess age-related changes and gender differences across Holland's (1959, 1997) RIASEC categories and composite dimensions (people, things, data, and ideas). Results showed that mean-level interest scores generally increase with age, but effect sizes varied across interest categories and developmental periods. Adolescence was defined by two broad patterns of change: interest scores generally decreased during early adolescence, but then increased during late adolescence. During young adulthood, the most striking changes were found across the people and things orientations. Interests involving people tended to increase (artistic, social, and enterprising), whereas interests involving things either decreased (conventional) or remained constant (realistic and investigative). Gender differences associated with occupational stereotypes reached a lifetime peak during early adolescence, then tended to decrease in all subsequent age periods. Overall findings suggest there are normative changes in vocational interests from adolescence to adulthood, with important implications for developmental theories and the applied use of interests. (PsycINFO Database Record

A meta-analysis of longitudinal associations between substance use and interpersonal attachment security.

Substance use has long been associated with close relationship distress. Although the direction of influence for this association has not been established, it has often been assumed that substance use is the causal agent and that close relationship distress is the effect. But research seeking to establish temporal precedence in this link has produced mixed findings. Further, theoretical models of substance use and close relationship processes present the plausibility of the inverse pathway-that insecure close relationships may serve as a vulnerability factor for the development of later substance problems. The current review applies an attachment-theoretical framework to the association between close social bonds and substance use and substance-related problems. Targeting longitudinal studies of attachment and substance use, we examined 665 effect sizes drawn from 34 samples (total N = 56,721) spanning time frames ranging from 1 month to 20 years (M = 3.8 years). Results revealed a significant prospective correlation between earlier attachment and later substance use (r = -.11, 95% CI [-.14, -0.08]). Further, cross-lagged coefficients were calculated which parsed auto-regressive effects, indicating that lower attachment security temporally preceded increases in substance use (r = -.05, 95% CI [-.06, -.04]). Analyses further indicated that the pathway from earlier attachment to later substance use was significantly stronger than that from earlier substance use to later attachment. Results also revealed several moderators of the attachment-substance use link. These findings suggest that insecure attachment may be a vulnerability factor for substance use, and indicate close relationship quality as a promising line of inquiry in research on substance use disorder risk. (PsycINFO Database Record